What we measure

Looking past the skin, at the metabolism underneath.

You collect blood and urine at home and send them to Athens, where they are analysed by Metabolomic Analysis® in an internationally accredited laboratory.

Who comes to us

In Korea, most people who come to us
are parents of children with eczema.

Creams worked only while they lasted, and there was no standard for what to feed a child. Since 2017, the majority of the cases we have guided have been atopic dermatitis.

Read Damin’s story See the process

Markers

What the analysis looks at

Very small molecules in the body are measured to show how the metabolism is actually working. These are the ten areas Metabolomic Analysis® examines at a cellular level.

  1. DeficienciesVitamins, enzymes, minerals, amino acids and omega-3 fatty acids
  2. InsulinInsulin resistance and the factors causing it
  3. InflammationInflammation, and how efficiently the body repairs itself
  4. EnergyEnergy production — mitochondrial function
  5. Oxidative stressThe degree of oxidative stress
  6. AntioxidantThe body’s antioxidant capacity
  7. MicrobiomeThe state of the gut flora
  8. MetabolismDisorders in protein, carbohydrate and lipid metabolism
  9. NeurotransmittersNeurotransmitter metabolism — serotonin, dopamine, adrenaline, GABA
  10. HormonesHormone function disorders

Specimens

Blood and urine, together.

The two samples show different things, which is why both are collected.

Blood

Fatty acids

Fatty acids and their metabolites are analysed in blood — the composition of the fats that build cell membranes and take part in inflammatory processes.

Urine

Organic acids

Organic acids, the intermediate products of metabolism, are analysed in urine. They carry traces of energy metabolism, gut environment and how nutrients are used.

Samples are collected at home using the kit that is posted to you. Instructions, fasting conditions and storage and drying requirements are all included.

Laboratory

Where it is analysed.

Metabolomic analysis is not comparable to an ordinary laboratory test. It is highly specialised and is carried out in only a small number of laboratories worldwide that meet very high standards. The clinic’s laboratory takes part in the quality control programmes run by the organisations below.

ERNDIM

European Network of Laboratories for Inherited Metabolic Diseases — the scientific body holding the highest laboratory standards worldwide.

CDC

Quality control programme of the US Centers for Disease Control and Prevention.

NIST

Quality control programme of the US National Institute of Standards and Technology.

ISO 17025 / 15189

International standards for testing laboratories and for medical laboratories.

Source: Metabolomic Medicine clinic (drtsoukalas.com). The clinic interprets results on the basis of more than 25,000 patients.

After the result

What happens once results arrive.

The analysis identifies what can be adjusted through diet, lifestyle and nutritional supplementation. Based on the results, the clinic proposes the following.

Regimen

Replenishing what is missing

Specific vitamins, minerals and amino acids are prescribed by the clinic’s physicians according to the deficiencies found.

Diet

A diet matched to you

A nutrition plan built around your metabolic profile — what to increase and what to reduce, decided individually.

Please note — for any acute condition, for a diagnosis, or for prescription medicine, you should be seen by a physician where you live. This test does not replace that. Tell us about any medication you are taking; the clinic’s physicians will review it.

What you receive

Three things, in order.

They do not arrive together. The report comes first, the diet plan follows, and the written interview comes last.

01

Test report

An English report of about 15 pages explaining the laboratory results, with recommendations.

02

Personalised diet plan

A diet plan built on the analysis (English, about 6 pages). It arrives later than the report.

03

Written interview

Your questions about the results and the diet are collected and put to the clinic’s physicians and nutritionists, and the answers are returned to you.

Scope

What the clinic treats

The clinic mainly sees patients in the categories below. In Korea the cases we guide are mostly atopic dermatitis, but the test and the clinic’s practice are broader than that.

Autoimmune

Autoimmune conditions

Conditions in which the body attacks its own tissues and organs — Hashimoto’s thyroiditis, ulcerative colitis, multiple sclerosis, psoriasis, rheumatoid arthritis, lupus and others.

Chronic

Chronic conditions

Health problems lasting more than three months — diabetes, metabolic syndrome, insulin resistance, thyroid and cardiovascular disease, gastrointestinal disorders, chronic fatigue, obesity, hormone problems.

Prevention

Prevention

For healthy people who want to know their deficiencies and metabolic state in advance.

Whether a patient can be accepted is decided by the clinic’s physicians, taking health status and current medication into account.

References

What is this based on?

Metabolomic analysis rests on research published in peer-reviewed journals. Below is a selection of papers involving the research group of Dr. Dimitris Tsoukalas at Metabolomic Medicine.

  1. Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases Tsoukalas D. et al. · Frontiers in Molecular Biosciences · 2019
  2. Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases Sarandi E., Tsoukalas D. et al. · Advances in Clinical Chemistry, Elsevier · 2020
  3. Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment Tsoukalas D., Sarandi E. · BMJ Nutrition, Prevention & Health · 2020
  4. Application of metabolomics: focus on the quantification of organic acids in healthy adults Tsoukalas D. et al. · International Journal of Molecular Medicine · 2017
  5. Application of metabolomics part II: focus on fatty acids and their metabolites in healthy adults Tsoukalas D. et al. · International Journal of Molecular Medicine · 2019
  6. Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma Papamichael M.M., Tsoukalas D. et al. · Nutrition Research · 2018

This page explains what the test measures. It is not intended to diagnose, treat, cure or prevent any disease, and does not replace medical advice. Interpretation of results and any prescription are the responsibility of the clinic’s physicians.

Contact

Let’s talk first.

Send us a message and we will arrange a call. We listen to your situation first, and decide together whether testing makes sense for you now. The first consultation is free.